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Many times people ask the question ‘is leptin resistance real?’. But first, it is important to understand what leptin is.
What exactly is leptin?
Leptin is a powerful and influential hormone produced by fat cells. Your fat, through leptin, tells your brain if you should be hungry, eat and make more fat, if it should reproduce or (in part by controlling your insulin) if you should participate in maintenance and repair.
In summary, leptin is the way your fat stores talk to your brain and let you know how much energy is available and most importantly, what to do with it.
Therefore, leptin could be the number one food chain in terms of metabolic importance and relevance in diseases.
If your leptin signaling is working properly, when your fat stores are “full,” this extra fat will cause an increase in the level of leptin, which signals your brain to stop feeling hungry, stop eating, stop storing fat and start burning that extra fat.
Controlling hunger is a form (although not the only one) in which leptin controls energy storage. Hunger is a powerful, ancient and entrenched way that if you stimulate enough, it will make you eat and store more energy.
The only way to eat less in the long term is by not being hungry and the only way to do it is by controlling the hormones that regulate hunger, of which the main one is leptin.
Update: leptitox is a newly discovered ground-breaking supplement program that addresses the root cause and breaks the devastating cycle of weight gain once and for all.
What Produces Leptin and Is leptin resistance real?
It has its origin in various tissues, mainly in adipose tissue (body fat) and is secreted into the blood, where it travels to the brain and other tissues, causing fat loss, decreased appetite or other functions, depending on where it acts.
The complex systems that regulate the physiopathogenesis of obesity have been the subject of intense research in recent years. This is because obesity is a disorder of high prevalence worldwide, especially in industrialized countries and is considered one of the main health problems.
Under normal conditions when there is an increase in fat in the body, leptin acts on the hypothalamus (a gland in the brain) to decrease appetite and increase basal metabolism.
In obese people, the secretion of leptin increases, reaching values four times higher than in the non-obese, which reflects a state of resistance to leptin (ie the hormone is but cannot act).
This hormone is secreted into the bloodstream primarily by adipose tissue, stomach, and some liver cells. It is also synthesized by the placenta during pregnancy implantation symptoms You Should Know and is secreted into the maternal circulation, so its concentration rises during normal pregnancy, especially in the second and third trimesters.
The presence of gastric leptin (in the stomach), and its response to food, suggest the participation of this hormone in the acute control of intake.
Leptin performs most of its metabolic effects by interacting with its specific receptors located in the central nervous system and peripheral tissues.
In addition to the existence of leptin receptors in the brain, they are found in peripheral organs, which broadens their range of action.
As for peripheral tissues they are found in the lung, kidney, liver, pancreas, adrenal cortex, ovaries, testicles, muscle-skeletal, hematopoietic cells, adipose tissue, and gastrointestinal tract.
In whom are leptin values increased?
Obese subjects have elevated leptin levels. After weight loss, leptin levels, which decrease below the estimated value based on fat mass, may indicate to the brain the sufficiency of fatty deposits.
How does Leptin work
At the level of the brain, leptin acts by inhibiting intake (loss of appetite), activates energy expenditure (fat loss) and affects numerous metabolic processes.
Leptin participates in the medium-term control of the energy balance. Genetic defects that involve the absence of leptin in mice and humans, determine the early onset of morbid obesity.
Leptin travels through the blood and its plasma levels correlate with total fat mass.
What functions does it have besides being related to obesity?
- Participates in the inflammatory response while modifying immune function. (that is, it is related to the immune system)
- It is involved in the regulation of the onset of puberty and in the function of reproduction. It has been shown that extremely thin adolescents begin puberty late, so it has been suggested that leptin informs the brain about the amount of fat mass that exists for the onset of female puberty and reproduction.
- It has the effect of stimulating gonadal function (sex glands), creating a union between adipose tissue and the function of reproduction. This union may be the one that would explain the reduction in fertility found in very thin women, such as athletes or ballet dancers and that the secretion of leptin could be the signal to the gonads when there is already enough energy stored to sustain a pregnancy
- Modify glucose metabolism. Stimulates lipolysis in the adipocyte, causes a modification of the distribution of lipids in muscle tissue
- It constitutes a fundamental metabolic signal that modulates the secretion of growth hormone.
Is leptin resistance to the cause of Obesity?
It has been suggested that obesity occurs because after a certain amount of leptin its transport system from the brain to the blood becomes saturated or because an alteration in its receptors develops at the level of the brain.
Due to this state of resistance is that the vast majority of obese people have an exaggerated appetite (hyperphagia) despite having an excess of leptin, that is, this hormone sends information that is not recorded by the brain producing a decrease in reply
Recent prospects in the application of leptin.
Identifying the genes regulated by leptin has improved knowledge of how leptin causes its effects on weight and appetite and has also offered new drug design goals that stimulate weight loss.
The growing knowledge of this hormone has opened up new perspectives in the difficult therapeutic field of obesity. The “leptino-resistance” mechanism has been unlocked, resulting in a very effective therapeutic weapon known as leptitox for the treatment of the obese patient.